mdr1 gene การใช้

• Dogs can have both the defective MDR1 gene and have inactivated CYP3A enzymes.
• Dogs with the MDR1 gene mutation may have adverse reactions when given certain drugs.
• Rough Collies may carry a mutant Mdr1 gene that results in a sensitivity to Ivermectin and related drugs.
• The mutation of the MDR1 gene is found in Scottish Collies and related breeds worldwide and affects approximately 80 % of Scottish Collie dogs in the United States.
• According to the College of Veterinary Medicine at Washington State University, the Shetland Sheepdog, and many other herding breeds, have a risk of being born with a MDR1 Gene Mutation, with about 15 % of individuals affected.